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Micromachines 2017, 8(6), 171; doi:10.3390/mi8060171

Dynamical Modeling and Analysis of Viscoelastic Properties of Single Cells

State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
University of Chinese Academy of Sciences, Beijing 100049, China
Authors to whom correspondence should be addressed.
Academic Editors: Aaron T. Ohta and Wenqi Hu
Received: 14 April 2017 / Revised: 13 May 2017 / Accepted: 22 May 2017 / Published: 1 June 2017
(This article belongs to the Special Issue Microdevices and Microsystems for Cell Manipulation)
View Full-Text   |   Download PDF [3726 KB, uploaded 1 June 2017]   |  


A single cell can be regarded as a complex network that contains thousands of overlapping signaling pathways. The traditional methods for describing the dynamics of this network are extremely complicated. The mechanical properties of a cell reflect the cytoskeletal structure and composition and are closely related to the cellular biological functions and physiological activities. Therefore, modeling the mechanical properties of single cells provides the basis for analyzing and controlling the cellular state. In this study, we developed a dynamical model with cellular viscoelasticity properties as the system parameters to describe the stress-relaxation phenomenon of a single cell indented by an atomic force microscope (AFM). The system order and parameters were identified and analyzed. Our results demonstrated that the parameters identified using this model represent the cellular mechanical elasticity and viscosity and can be used to classify cell types. View Full-Text
Keywords: dynamical modeling; mechanical properties; principal component analysis; atomic force microscopy; viscoelasticity dynamical modeling; mechanical properties; principal component analysis; atomic force microscopy; viscoelasticity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, B.; Wang, W.; Wang, Y.; Liu, B.; Liu, L. Dynamical Modeling and Analysis of Viscoelastic Properties of Single Cells. Micromachines 2017, 8, 171.

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