Next Article in Journal / Special Issue
The Self-Propulsion of the Spherical Pt–SiO2 Janus Micro-Motor
Previous Article in Journal
Localized Single-Cell Lysis and Manipulation Using Optothermally-Induced Bubbles
Previous Article in Special Issue
Advances in Single Cell Impedance Cytometry for Biomedical Applications
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessFeature PaperReview
Micromachines 2017, 8(4), 124; doi:10.3390/mi8040124

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

1
Future Industries Institute, University of South Australia, Mawson Lakes Blvd., Mawson Lakes, 5098 SA, Australia
2
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 VIC, Australia
Current address: National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia.
*
Author to whom correspondence should be addressed.
Academic Editors: Weihua Li, Hengdong Xi and Say Hwa Tan
Received: 28 February 2017 / Revised: 6 April 2017 / Accepted: 7 April 2017 / Published: 12 April 2017
(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
View Full-Text   |   Download PDF [3123 KB, uploaded 12 April 2017]   |  

Abstract

Many unique chemical compounds and nanomaterials are being developed, and each one requires a considerable range of in vitro and/or in vivo toxicity screening in order to evaluate their safety. The current methodology of in vitro toxicological screening on cells is based on well-plate assays that require time-consuming manual handling or expensive automation to gather enough meaningful toxicology data. Cost reduction; access to faster, more comprehensive toxicity data; and a robust platform capable of quantitative testing, will be essential in evaluating the safety of new chemicals and nanomaterials, and, at the same time, in securing the confidence of regulators and end-users. Microfluidic chips offer an alternative platform for toxicity screening that has the potential to transform both the rates and efficiency of nanomaterial testing, as reviewed here. The inherent advantages of microfluidic technologies offer high-throughput screening with small volumes of analytes, parallel analyses, and low-cost fabrication. View Full-Text
Keywords: microfluidics; cytotoxicity; nanotoxicity; nanoparticles; screening microfluidics; cytotoxicity; nanotoxicity; nanoparticles; screening
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

McCormick, S.C.; Kriel, F.H.; Ivask, A.; Tong, Z.; Lombi, E.; Voelcker, N.H.; Priest, C. The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments. Micromachines 2017, 8, 124.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top