Observation Interface of PDMS Membrane in a Microfluidic Chip Based on One-Step Molding
AbstractNowadays, researchers are focusing on sorting, characterizing and detecting micron or submicron particles or bacteria in microfluidic chips. However, some contradictions hinder the applications of conventional microfluidic chips, including the low working distance of high resolving power microscopy and the low light transmittance of conventional microfluidic chips. In this paper, a rapid and readily accessible microfluidic fabrication method is presented to realize observation with high magnification microscopy. With the one-step molding process, the interconnections, the thin observation interface of polydimethylsiloxane (PDMS) membrane and microfluidic channels were integrated into an intact PDMS replica. Three kinds of PDMS replicas with different auxiliary beams were designed and optimized by leakage experiments and analytical software. The observation interfaces of a 170 μm thickness PDMS membrane enlarges the application domain of microfluidic chips. By adopting a solution of high magnification observation, microfluidic devices could be applied widely in medical science, biology and material science. View Full-Text
Share & Cite This Article
Chen, X.; Hou, S.; Chu, J.; Xiong, Y.; Xiong, P.; Liu, G.; Tian, Y. Observation Interface of PDMS Membrane in a Microfluidic Chip Based on One-Step Molding. Micromachines 2017, 8, 64.
Chen X, Hou S, Chu J, Xiong Y, Xiong P, Liu G, Tian Y. Observation Interface of PDMS Membrane in a Microfluidic Chip Based on One-Step Molding. Micromachines. 2017; 8(3):64.Chicago/Turabian Style
Chen, Xiangyu; Hou, Shuangyue; Chu, Jian; Xiong, Ying; Xiong, Penghui; Liu, Gang; Tian, Yangchao. 2017. "Observation Interface of PDMS Membrane in a Microfluidic Chip Based on One-Step Molding." Micromachines 8, no. 3: 64.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.