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Micromachines 2017, 8(12), 347; https://doi.org/10.3390/mi8120347

Methods of Micropatterning and Manipulation of Cells for Biomedical Applications

1
CIC, Instituto Politécnico Nacional (IPN), Av. Juan de Dios Bátiz S/N, Nueva Industrial Vallejo, 07738 Mexico City, Mexico
2
CONACYT-CNMN, Instituto Politécnico Nacional (IPN), Av. Luis Enrique Erro s/n, Nueva Industrial Vallejo, 07738 Mexico City, Mexico
3
ENCB, Instituto Politécnico Nacional (IPN), Av. Wilfrido Massieu, Unidad Adolfo López Mateos, 07738 Mexico City, Mexico
4
ITAV-CNRS, Université de Toulouse, CNRS, Toulouse, France
5
LAAS-CNRS, Université de Toulouse, CNRS, Toulouse, France
*
Authors to whom correspondence should be addressed.
Received: 7 November 2017 / Revised: 27 November 2017 / Accepted: 28 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Medical Microdevices and Micromachines)
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Abstract

Micropatterning and manipulation of mammalian and bacterial cells are important in biomedical studies to perform in vitro assays and to evaluate biochemical processes accurately, establishing the basis for implementing biomedical microelectromechanical systems (bioMEMS), point-of-care (POC) devices, or organs-on-chips (OOC), which impact on neurological, oncological, dermatologic, or tissue engineering issues as part of personalized medicine. Cell patterning represents a crucial step in fundamental and applied biological studies in vitro, hence today there are a myriad of materials and techniques that allow one to immobilize and manipulate cells, imitating the 3D in vivo milieu. This review focuses on current physical cell patterning, plus chemical and a combination of them both that utilizes different materials and cutting-edge micro-nanofabrication methodologies. View Full-Text
Keywords: cell patterning and manipulation; mammalian and bacterial cells; micro-nanofabrication; microfluidics; organs-on-chips (OOC); biomedical microelectromechanical systems (bioMEMS); point-of-care (POC); soft lithography cell patterning and manipulation; mammalian and bacterial cells; micro-nanofabrication; microfluidics; organs-on-chips (OOC); biomedical microelectromechanical systems (bioMEMS); point-of-care (POC); soft lithography
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Martinez-Rivas, A.; González-Quijano, G.K.; Proa-Coronado, S.; Séverac, C.; Dague, E. Methods of Micropatterning and Manipulation of Cells for Biomedical Applications. Micromachines 2017, 8, 347.

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