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Micromachines 2017, 8(1), 8; doi:10.3390/mi8010008

Continuous Jetting of Alginate Microfiber in Atmosphere Based on a Microfluidic Chip

1,2
,
3
,
1,2
and
1,2,*
1
Department of Precision Instruments, Tsinghua University, Beijing 100084, China
2
The State Key Laboratory of Precision Measurement Technology and Instrumentation, Tsinghua University, Beijing 100084, China
3
Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Institute of Nuclear and New Energy Technology of Tsinghua University, Beijing 100084, China
*
Author to whom correspondence should be addressed.
Academic Editors: Chia-Hung Chen, Ai Qun Liu and Nam-Trung Nguyen
Received: 2 October 2016 / Revised: 29 November 2016 / Accepted: 22 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Optofluidics 2016)
View Full-Text   |   Download PDF [5143 KB, uploaded 4 January 2017]   |  

Abstract

We present a method based on a microfluidic chip that produces continuous jetting of alginate microfiber in the atmosphere to facilitate its collection and assembly. Through the analysis of the factors influencing the microfiber jetting, the principle and some microfluidic chip design criteria are discussed. A special nozzle is designed near the chip outlet, and deionized water is introduced into the microchannel through the nozzle to increase the flux and thus to prevent drop formation around the outlet which impedes the continuous jetting of microfiber. The experiments have reported the effectiveness of the proposed structure and shown that the introduction of sheath flow promotes the stability of the flow field in the microchannel and does not affect the morphology of microfiber. Simulations of velocity and pressure distribution in the microchannel are also conducted. Further, the jetting microfibers are collected and assembled into various 3D complex fiber-based macroscopic structures through patterning or reeling. Since the proposed structure is rather simple and can be easily integrated into other complex structures without adding more soft-lithographical steps, microfibers with various morphology and function can be synthesized and collected in a single chip, which can be applied to various fields, such as tissue engineering, biotechnology, and drug discovery. View Full-Text
Keywords: microfluidic chip; alginate microfiber; jet; nozzle; sheath flow; tissue engineering microfluidic chip; alginate microfiber; jet; nozzle; sheath flow; tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhao, J.; Xiong, W.; Yu, N.; Yang, X. Continuous Jetting of Alginate Microfiber in Atmosphere Based on a Microfluidic Chip. Micromachines 2017, 8, 8.

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