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Open AccessCommunication
Micromachines 2017, 8(1), 16; doi:10.3390/mi8010016

Complete Procedure for Fabrication of a Fused Silica Ultrarapid Microfluidic Mixer Used in Biophysical Measurements

1
Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824, USA
2
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yong Kweon Suh
Received: 16 November 2016 / Revised: 27 December 2016 / Accepted: 3 January 2017 / Published: 7 January 2017
(This article belongs to the Collection Lab-on-a-Chip)
View Full-Text   |   Download PDF [3322 KB, uploaded 7 January 2017]   |  

Abstract

In this paper we present a method to fabricate a fused silica microfluidic device by employing low viscosity KMPR photoresists. The resulting device is a continuous-flow microfluidic mixer based on hydrodynamic focusing. The advantages of this new fabrication method compared to the traditional approach using a poly-silicon mask are simplification, and time and cost reduction, while still preserving the quality and the performance of the mixers. This process results in devices in which the focusing channel has an aspect ratio of 10:1. The newly-fabricated mixer is successfully used to observe the folding of the Pin1 WW domain at the microsecond time scale. View Full-Text
Keywords: microfluidic mixer; protein folding; KMPR; fused silica microfluidic mixer; protein folding; KMPR; fused silica
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Izadi, D.; Nguyen, T.; Lapidus, L.J. Complete Procedure for Fabrication of a Fused Silica Ultrarapid Microfluidic Mixer Used in Biophysical Measurements. Micromachines 2017, 8, 16.

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