Next Article in Journal
3D Finite Element Simulation of Graphene Nano-Electro-Mechanical Switches
Next Article in Special Issue
Micro/Nano Devices for Chemical Analysis
Previous Article in Journal
Study of a Microfluidic Chip Integrating Single Cell Trap and 3D Stable Rotation Manipulation
Previous Article in Special Issue
A Method of Three-Dimensional Micro-Rotational Flow Generation for Biological Applications
Article Menu

Export Article

Open AccessArticle
Micromachines 2016, 7(8), 142; doi:10.3390/mi7080142

High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel

1
Department of Hemolysis and Apheresis, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan
2
Deparment of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Manabu Tokeshi and Kiichi Sato
Received: 2 May 2016 / Revised: 2 August 2016 / Accepted: 10 August 2016 / Published: 15 August 2016
(This article belongs to the Special Issue Micro/Nano Devices for Chemical Analysis)
View Full-Text   |   Download PDF [2609 KB, uploaded 15 August 2016]   |  

Abstract

Microfluidics has been used to perform various chemical operations for pL–nL volumes of samples, such as mixing, reaction and separation, by exploiting diffusion, viscous forces, and surface tension, which are dominant in spaces with dimensions on the micrometer scale. To further develop this field, we previously developed a novel microfluidic device, termed a microdroplet collider, which exploits spatially and temporally localized kinetic energy. This device accelerates a microdroplet in the gas phase along a microchannel until it collides with a target. We demonstrated 6000-fold faster mixing compared to mixing by diffusion; however, the droplet acceleration was not optimized, because the experiments were conducted for only one droplet size and at pressures in the 10–100 kPa range. In this study, we investigated the acceleration of a microdroplet using a high-pressure (MPa) control system, in order to achieve higher acceleration and kinetic energy. The motion of the nL droplet was observed using a high-speed complementary metal oxide semiconductor (CMOS) camera. A maximum droplet velocity of ~5 m/s was achieved at a pressure of 1–2 MPa. Despite the higher fluid resistance, longer droplets yielded higher acceleration and kinetic energy, because droplet splitting was a determining factor in the acceleration and using a longer droplet helped prevent it. The results provide design guidelines for achieving higher kinetic energies in the microdroplet collider for various microfluidic applications. View Full-Text
Keywords: microfluidics; microchannel; droplet; gas phase microfluidics; microchannel; droplet; gas phase
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kazoe, Y.; Yamashiro, I.; Mawatari, K.; Kitamori, T. High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel. Micromachines 2016, 7, 142.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top