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Micromachines 2016, 7(5), 90; doi:10.3390/mi7050090

A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level

1
Department of Electrical, Computer, and Biomedical Engineering, Università di Pavia, Via Ferrata 5A, Pavia 27100, Italy
2
Institute of Photonics and Nanotechnology, CNR & Department of Physics, Politecnico di Milano, Piazza Leonardo da Vinci 32, Milano 20133, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Shih-Kang Fan, Da-Jeng Yao and Yi-Chung Tung
Received: 10 March 2016 / Revised: 14 April 2016 / Accepted: 21 April 2016 / Published: 13 May 2016
(This article belongs to the Special Issue Optofluidics 2015)

Abstract

This paper presents a comprehensive review of the development of the optical stretcher, a powerful optofluidic device for single cell mechanical study by using optical force induced cell stretching. The different techniques and the different materials for the fabrication of the optical stretcher are first summarized. A short description of the optical-stretching mechanism is then given, highlighting the optical force calculation and the cell optical deformability characterization. Subsequently, the implementations of the optical stretcher in various cell-mechanics studies are shown on different types of cells. Afterwards, two new advancements on optical stretcher applications are also introduced: the active cell sorting based on cell mechanical characterization and the temperature effect on cell stretching measurement from laser-induced heating. Two examples of new functionalities developed with the optical stretcher are also included. Finally, the current major limitation and the future development possibilities are discussed. View Full-Text
Keywords: single-cell analysis; microfluidics; optofluidics; optical stretcher; mechanical properties characterization single-cell analysis; microfluidics; optofluidics; optical stretcher; mechanical properties characterization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, T.; Bragheri, F.; Minzioni, P. A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level. Micromachines 2016, 7, 90.

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