Microfabricated Physiological Models for In Vitro Drug Screening Applications
AbstractMicrofluidics and microfabrication have recently been established as promising tools for developing a new generation of in vitro cell culture microdevices. The reduced amounts of reagents employed within cell culture microdevices make them particularly appealing to drug screening processes. In addition, latest advancements in recreating physiologically relevant cell culture conditions within microfabricated devices encourage the idea of using such advanced biological models in improving the screening of drug candidates prior to in vivo testing. In this review, we discuss microfluidics-based models employed for chemical/drug screening and the strategies to mimic various physiological conditions: fine control of 3D extra-cellular matrix environment, physical and chemical cues provided to cells and organization of co-cultures. We also envision future directions for achieving multi-organ microfluidic devices. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Ugolini, G.S.; Cruz-Moreira, D.; Visone, R.; Redaelli, A.; Rasponi, M. Microfabricated Physiological Models for In Vitro Drug Screening Applications. Micromachines 2016, 7, 233.
Ugolini GS, Cruz-Moreira D, Visone R, Redaelli A, Rasponi M. Microfabricated Physiological Models for In Vitro Drug Screening Applications. Micromachines. 2016; 7(12):233.Chicago/Turabian Style
Ugolini, Giovanni S.; Cruz-Moreira, Daniela; Visone, Roberta; Redaelli, Alberto; Rasponi, Marco. 2016. "Microfabricated Physiological Models for In Vitro Drug Screening Applications." Micromachines 7, no. 12: 233.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.