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Micromachines 2016, 7(11), 194; doi:10.3390/mi7110194

Acoustically Triggered Disassembly of Multilayered Polyelectrolyte Thin Films through Gigahertz Resonators for Controlled Drug Release Applications

State Key Laboratory of Precision Measuring Technology & Instruments, Tianjin University, Tianjin 300072, China
The authors contributed equally to this work.
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Academic Editors: Renshi Sawada and Nam-Trung Nguyen
Received: 15 September 2016 / Revised: 13 October 2016 / Accepted: 19 October 2016 / Published: 1 November 2016
(This article belongs to the Special Issue Recent Advances of BioMEMS and Their Applications)
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Abstract

Controlled drug release has a high priority for the development of modern medicine and biochemistry. To develop a versatile method for controlled release, a miniaturized acoustic gigahertz (GHz) resonator is designed and fabricated which can transfer electric supply to mechanical vibrations. By contacting with liquid, the GHz resonator directly excites streaming flows and induces physical shear stress to tear the multilayered polyelectrolyte (PET) thin films. Due to the ultra-high working frequency, the shear stress is greatly intensified, which results in a controlled disassembling of the PET thin films. This technique is demonstrated as an effective method to trigger and control the drug release. Both theory analysis and controlled release experiments prove the thin film destruction and the drug release. View Full-Text
Keywords: controlled drug release; layer-by-layer (LbL); bulk acoustic resonator; MEMS controlled drug release; layer-by-layer (LbL); bulk acoustic resonator; MEMS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, Z.; Tang, Z.; Liu, W.; Zhang, H.; Lu, Y.; Wang, Y.; Pang, W.; Zhang, H.; Duan, X. Acoustically Triggered Disassembly of Multilayered Polyelectrolyte Thin Films through Gigahertz Resonators for Controlled Drug Release Applications. Micromachines 2016, 7, 194.

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