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Micromachines 2016, 7(10), 183; doi:10.3390/mi7100183

Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant

1
IHP, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany
2
Department of Biotechnology, Technical University Berlin, ACK24, Ackerstr. 76, 13355 Berlin, Germany
3
Acreo Swedish ICT AB, Box 787, SE-60117 Norrköping, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Kenichi Takahata and Joost Lötters
Received: 28 June 2016 / Revised: 23 September 2016 / Accepted: 28 September 2016 / Published: 9 October 2016
(This article belongs to the Special Issue Implantable Microsystems)
View Full-Text   |   Download PDF [2057 KB, uploaded 9 October 2016]   |  

Abstract

An integration concept for an implantable biosensor for the continuous monitoring of blood sugar levels is presented. The system architecture is based on technical modules used in cardiovascular implants in order to minimize legal certification efforts for its perspective usage in medical applications. The sensor chip operates via the principle of affinity viscometry, which is realized by a fully embedded biomedical microelectromechanical systems (BioMEMS) prepared in 0.25-µm complementary metal–oxide–semiconductor (CMOS)/BiCMOS technology. Communication with a base station is established in the 402–405 MHz band used for medical implant communication services (MICS). The implant shall operate within the interstitial tissue, and the hermetical sealing of the electronic system against interaction with the body fluid is established using titanium housing. Only the sensor chip and the antenna are encapsulated in an epoxy header closely connected to the metallic housing. The study demonstrates that biosensor implants for the sensing of low-molecular-weight metabolites in the interstitial may successfully rely on components already established in cardiovascular implantology. View Full-Text
Keywords: biosensor; affinity assay; continuous glucose monitoring; BioMEMS; sterilization; metallic housing; titanium; medical implant biosensor; affinity assay; continuous glucose monitoring; BioMEMS; sterilization; metallic housing; titanium; medical implant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Birkholz, M.; Glogener, P.; Glös, F.; Basmer, T.; Theuer, L. Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant. Micromachines 2016, 7, 183.

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