Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant
AbstractAn integration concept for an implantable biosensor for the continuous monitoring of blood sugar levels is presented. The system architecture is based on technical modules used in cardiovascular implants in order to minimize legal certification efforts for its perspective usage in medical applications. The sensor chip operates via the principle of affinity viscometry, which is realized by a fully embedded biomedical microelectromechanical systems (BioMEMS) prepared in 0.25-µm complementary metal–oxide–semiconductor (CMOS)/BiCMOS technology. Communication with a base station is established in the 402–405 MHz band used for medical implant communication services (MICS). The implant shall operate within the interstitial tissue, and the hermetical sealing of the electronic system against interaction with the body fluid is established using titanium housing. Only the sensor chip and the antenna are encapsulated in an epoxy header closely connected to the metallic housing. The study demonstrates that biosensor implants for the sensing of low-molecular-weight metabolites in the interstitial may successfully rely on components already established in cardiovascular implantology. View Full-Text
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Birkholz, M.; Glogener, P.; Glös, F.; Basmer, T.; Theuer, L. Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant. Micromachines 2016, 7, 183.
Birkholz M, Glogener P, Glös F, Basmer T, Theuer L. Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant. Micromachines. 2016; 7(10):183.Chicago/Turabian Style
Birkholz, Mario; Glogener, Paul; Glös, Franziska; Basmer, Thomas; Theuer, Lorenz. 2016. "Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant." Micromachines 7, no. 10: 183.
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