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Micromachines 2015, 6(7), 813-830; doi:10.3390/mi6070813

Effect of Laser-Induced Heating on Raman Measurement within a Silicon Microfluidic Channel

1
School of Mechanical Engineering, Shanghai Institute of Technology, Shanghai 201418, China
2
Key Laboratory of Pressurized Systems and Safety, Ministry of Education, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
3
School of Software and Microelectronics at Wuxi, Peking University, Wuxi 214125, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jeong-Bong Lee
Received: 24 April 2015 / Revised: 10 June 2015 / Accepted: 19 June 2015 / Published: 29 June 2015
(This article belongs to the Collection Lab-on-a-Chip)
View Full-Text   |   Download PDF [1007 KB, uploaded 29 June 2015]   |  

Abstract

When Raman microscopy is adopted to detect the chemical and biological processes in the silicon microfluidic channel, the laser-induced heating effect will cause a temperature rise in the sample liquid. This undesired temperature rise will mislead the Raman measurement during the temperature-influencing processes. In this paper, computational fluid dynamics simulations were conducted to evaluate the maximum local temperature-rise (MLT). Through the orthogonal analysis, the sensitivity of potential influencing parameters to the MLT was determined. In addition, it was found from transient simulations that it is reasonable to assume the actual measurement to be steady-state. Simulation results were qualitatively validated by experimental data from the Raman measurement of diffusion, a temperature-dependent process. A correlation was proposed for the first time to estimate the MLT. Simple in form and convenient for calculation, this correlation can be efficiently applied to Raman measurement in a silicon microfluidic channel. View Full-Text
Keywords: laser-induced heating; Raman measurement; microchannel; computational fluid dynamics laser-induced heating; Raman measurement; microchannel; computational fluid dynamics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lin, Y.; Yu, X.; Wang, Z.; Tu, S.-T.; Wang, Z. Effect of Laser-Induced Heating on Raman Measurement within a Silicon Microfluidic Channel. Micromachines 2015, 6, 813-830.

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