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Micromachines 2015, 6(12), 1903-1913; doi:10.3390/mi6121464

Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing

1
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 114 Nanta Str., Shenhe Dist., Shenyang 110016, China
2
University of the Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Sami Franssila
Received: 11 October 2015 / Revised: 23 November 2015 / Accepted: 27 November 2015 / Published: 4 December 2015
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Abstract

Fabrication of hydrogel microstructures has attracted considerable attention. A large number of applications, such as fabricating tissue engineering scaffolds, delivering drugs to diseased tissue, and constructing extracellular matrix for studying cell behaviors, have been introduced. In this article, an ultraviolet (UV)-curing method based on a digital micromirror device (DMD) for fabricating poly(ethylene glycol) diacrylate (PEGDA) hydrogel microstructures was presented. By controlling UV projection in real-time using a DMD as digital dynamic mask instead of a physical mask, polymerization of the pre-polymer solution could be controlled to create custom-designed hydrogel microstructures. Arbitrary microstructures could also be fabricated within several seconds (<5 s) using a single-exposure, providing a much higher efficiency than existing methods, while also offering a high degree of flexibility and repeatability. Moreover, different cell chains, which can be used for straightforwardly and effectively studying the cell interaction, were formed by fabricated PEGDA microstructures. View Full-Text
Keywords: microstructure fabrication; polymers; spatial light modulators; cell chains microstructure fabrication; polymers; spatial light modulators; cell chains
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, W.; Yu, H.; Liang, W.; Wang, Y.; Liu, L. Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing. Micromachines 2015, 6, 1903-1913.

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