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Micromachines 2015, 6(12), 1971-1983; doi:10.3390/mi6121468

Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

1
Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kgs. Lyngby 2800, Denmark
2
DFM A/S Matematiktorvet 307, Kgs. Lyngby 2800, Denmark
3
Department of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, Building 343, Kgs. Lyngby 2800, Denmark
4
Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan 20122, Italy
5
Department of Physics, Technical University of Denmark, Fysikvej, Building 309, Kgs. Lyngby 2800, Denmark
*
Authors to whom correspondence should be addressed.
Academic Editors: Shih-Kang Fan, Da-Jeng Yao and Yi-Chung Tung
Received: 7 November 2015 / Revised: 1 December 2015 / Accepted: 4 December 2015 / Published: 9 December 2015
(This article belongs to the Special Issue Optofluidics 2015)
View Full-Text   |   Download PDF [5138 KB, uploaded 9 December 2015]   |  

Abstract

We present a method to fabricate polymer optofluidic systems by means of injection molding that allow the insertion of standard optical fibers. The chip fabrication and assembly methods produce large numbers of robust optofluidic systems that can be easily assembled and disposed of, yet allow precise optical alignment and improve delivery of optical power. Using a multi-level chip fabrication process, complex channel designs with extremely vertical sidewalls, and dimensions that range from few tens of nanometers to hundreds of microns can be obtained. The technology has been used to align optical fibers in a quick and precise manner, with a lateral alignment accuracy of 2.7 ± 1.8 μm. We report the production, assembly methods, and the characterization of the resulting injection-molded chips for Lab-on-Chip (LoC) applications. We demonstrate the versatility of this technology by carrying out two types of experiments that benefit from the improved optical system: optical stretching of red blood cells (RBCs) and Raman spectroscopy of a solution loaded into a hollow core fiber. The advantages offered by the presented technology are intended to encourage the use of LoC technology for commercialization and educational purposes. View Full-Text
Keywords: fiber-based optofluidics; injection molding; optical trapping; hollow core fiber enhanced Raman spectroscopy fiber-based optofluidics; injection molding; optical trapping; hollow core fiber enhanced Raman spectroscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Matteucci, M.; Triches, M.; Nava, G.; Kristensen, A.; Pollard, M.R.; Berg-Sørensen, K.; Taboryski, R.J. Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications. Micromachines 2015, 6, 1971-1983.

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