Femtosecond Laser 3D Fabrication in Porous Glass for Micro- and Nanofluidic Applications
AbstractThe creation of complex three-dimensional (3D) fluidic systems composed of hollow micro- and nanostructures embedded in transparent substrates has attracted significant attention from both scientific and applied research communities. However, it is by now still a formidable challenge to build 3D micro- and nanofluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. As a direct and maskless fabrication technique, femtosecond laser micromachining provides a straightforward approach for high-precision, spatially-selective, modification inside transparent materials through nonlinear optical absorption. In this paper, we demonstrate rapid fabrication of high-aspect-ratio micro- and/or nanofluidic structures with various 3D configurations by femtosecond laser direct writing in porous glass substrates. Based on this approach, we demonstrate several functional micro- and nanofluidic devices including a 3D passive microfluidic mixer, a capillary electrophoresis (CE) analysis chip, and an integrated micro-nanofluidic system for single DNA analysis. The possible mechanisms behind the formation of high-aspect-ratio micro- and nanochannels are also discussed. This technology offers new opportunities to develop novel 3D micro-nanofluidic systems for a variety of lab-on-a-chip applications. View Full-Text
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Liao, Y.; Cheng, Y. Femtosecond Laser 3D Fabrication in Porous Glass for Micro- and Nanofluidic Applications. Micromachines 2014, 5, 1106-1134.
Liao Y, Cheng Y. Femtosecond Laser 3D Fabrication in Porous Glass for Micro- and Nanofluidic Applications. Micromachines. 2014; 5(4):1106-1134.Chicago/Turabian Style
Liao, Yang; Cheng, Ya. 2014. "Femtosecond Laser 3D Fabrication in Porous Glass for Micro- and Nanofluidic Applications." Micromachines 5, no. 4: 1106-1134.