Next Article in Journal
Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS
Next Article in Special Issue
Studies on the Presence of Mycotoxins in Biological Samples: An Overview
Previous Article in Journal
Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom’s Biological Role
Previous Article in Special Issue
Emerging Fusarium and Alternaria Mycotoxins: Occurrence, Toxicity and Toxicokinetics
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Toxins 2017, 9(8), 236; doi:10.3390/toxins9080236

Bacterial Toxins for Cancer Therapy

Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Albert-Str. 25, 79104 Freiburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Vernon L. Tesh
Received: 7 June 2017 / Revised: 21 July 2017 / Accepted: 26 July 2017 / Published: 28 July 2017
(This article belongs to the Collection Leading Opinions (Closed))
View Full-Text   |   Download PDF [1449 KB, uploaded 28 July 2017]   |  

Abstract

Several pathogenic bacteria secrete toxins to inhibit the immune system of the infected organism. Frequently, they catalyze a covalent modification of specific proteins. Thereby, they block production and/or secretion of antibodies or cytokines. Moreover, they disable migration of macrophages and disturb the barrier function of epithelia. In most cases, these toxins are extremely effective enzymes with high specificity towards their cellular substrates, which are often central signaling molecules. Moreover, they encompass the capacity to enter mammalian cells and to modify their substrates in the cytosol. A few molecules, at least of some toxins, are sufficient to change the cellular morphology and function of a cell or even kill a cell. Since many of those toxins are well studied concerning molecular mechanisms, cellular receptors, uptake routes, and structures, they are now widely used to analyze or to influence specific signaling pathways of mammalian cells. Here, we review the development of immunotoxins and targeted toxins for the treatment of a disease that is still hard to treat: cancer. View Full-Text
Keywords: bacterial toxin; cancer; specific transport; immunotoxin; targeted toxin bacterial toxin; cancer; specific transport; immunotoxin; targeted toxin
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zahaf, N.-I.; Schmidt, G. Bacterial Toxins for Cancer Therapy. Toxins 2017, 9, 236.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top