Table of Contents
Toxins, Volume 9, Issue 5 (May 2017)
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Cover Story (view full-size image) Venom from the African tarantula Monocentropus balfouri was found to contain two insecticidal [...] Read more. Venom from the African tarantula Monocentropus balfouri was found to contain two insecticidal peptides (Mb1a and Mb1b) that paralyse houseflies and blowflies but not cotton bollworms. Both peptides inhibit voltage-gated sodium and calcium channels in neurons isolated from the American cockroach as well as the cloned BgNaV1 channel from the German cockroach. Mb1a also induces a delay in fast inactivation of BgNaV1. Comparison of the sodium channels of the tested insect species revealed that sequence variations in the S1–S2 extracellular loops of the voltage sensor domains might underlie the differences in activity between different phyla. The photo was taken by Bastian Rast. View this paper.