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Toxins 2017, 9(4), 132; doi:10.3390/toxins9040132

Helicobacter pylori Strains and Gastric MALT Lymphoma

INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France
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Author to whom correspondence should be addressed.
Academic Editors: Jean E. Crabtree and Silja Wessler
Received: 24 January 2017 / Revised: 27 March 2017 / Accepted: 3 April 2017 / Published: 8 April 2017
(This article belongs to the Special Issue H. pylori Virulence Factors in the Induction of Gastric Cancer)
View Full-Text   |   Download PDF [252 KB, uploaded 8 April 2017]

Abstract

This article summarizes the main findings concerning Helicobacter pylori associated with gastric MALT lymphoma (GML). Considered together, GML strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. A particular Lewis antigen profile has been identified in GML strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of infiltrating lymphocytes. View Full-Text
Keywords: Helicobacter pylori; pathogenesis; virulence marker; cag pathogenicity island; MALT lymphoma Helicobacter pylori; pathogenesis; virulence marker; cag pathogenicity island; MALT lymphoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Floch, P.; Mégraud, F.; Lehours, P. Helicobacter pylori Strains and Gastric MALT Lymphoma. Toxins 2017, 9, 132.

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