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Toxins 2017, 9(3), 106; doi:10.3390/toxins9030106

Simultaneous Determination of Multi-Mycotoxins in Cereal Grains Collected from South Korea by LC/MS/MS

1
National Agricultural Products Quality Management Service, 5-3 Gimcheon innocity, Nam-myeon, Gimcheon City Gyeongsangbuk-do Province 39660, Korea
2
Department of Integrated Biomedical and Life Science, Korea University, Seoul 02841, Korea
3
Department of Food Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do 17546, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Aldo Laganà
Received: 4 January 2017 / Revised: 4 March 2017 / Accepted: 8 March 2017 / Published: 16 March 2017
(This article belongs to the Special Issue LC-MS/MS Method for Mycotoxin Analysis)
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Abstract

An improved analytical method compared with conventional ones was developed for simultaneous determination of 13 mycotoxins (deoxynivalenol, nivalenol, 3-acetylnivalenol, aflatoxin B1, aflatoxin B2, aflatoxin G1, aflatoxin G2, fumonisin B1, fumonisin B2, T-2, HT-2, zearalenone, and ochratoxin A) in cereal grains by liquid chromatography-tandem mass spectrometry (LC/MS/MS) after a single immunoaffinity column clean-up. The method showed a good linearity, sensitivity, specificity, and accuracy in mycotoxin determination by LC/MS/MS. The levels of 13 mycotoxins in 5 types of commercial grains (brown rice, maize, millet, sorghum, and mixed cereal) from South Korea were determined in a total of 507 cereal grains. Mycotoxins produced from Fusarium sp. (fumonisins, deoxynivalenol, nivalenol, and zearalenone) were more frequently (more than 5%) and concurrently detected in all cereal grains along with higher mean levels (4.3–161.0 ng/g) in positive samples than other toxins such as aflatoxins and ochratoxin A (less than 9% and below 5.2 ng/g in positive samples) from other fungal species. View Full-Text
Keywords: aflatoxins; deoxynivalenol; fumonisins; HT-2; nivalenol; ochratoxin A; T-2; zearalenone; grains; LC/MS/MS aflatoxins; deoxynivalenol; fumonisins; HT-2; nivalenol; ochratoxin A; T-2; zearalenone; grains; LC/MS/MS
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MDPI and ACS Style

Kim, D.-H.; Hong, S.-Y.; Kang, J.W.; Cho, S.M.; Lee, K.R.; An, T.K.; Lee, C.; Chung, S.H. Simultaneous Determination of Multi-Mycotoxins in Cereal Grains Collected from South Korea by LC/MS/MS. Toxins 2017, 9, 106.

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