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Toxins 2016, 8(7), 211; doi:10.3390/toxins8070211

Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid

1
Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012 Seville, Spain
2
Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, University of Seville, Avda. Americo Vespucio s/n., 41092 Seville, Spain
3
Department of Cell Biology, Faculty of Biology, University of Seville, Avda. Reina Mercedes s/n., 41012 Seville, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Carmela Fimognari
Received: 15 March 2016 / Revised: 11 June 2016 / Accepted: 1 July 2016 / Published: 8 July 2016
(This article belongs to the Special Issue Dietary and Non-Dietary Phytochemicals and Cancer)
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Abstract

Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular disorders, some cancers, diabetes, Parkinson and Alzheimer disease. Coffee consumption, however, has also been linked to an increased risk of developing some types of cancer, including bladder cancer in adults and leukemia in children of mothers who drink coffee during pregnancy. Since cancer is driven by the accumulation of DNA alterations, the ability of the coffee constituent caffeic acid to induce DNA damage in cells may play a role in the carcinogenic potential of this beverage. This carcinogenic potential may be exacerbated in cells with DNA repair defects. People with the genetic disease Fanconi Anemia have DNA repair deficiencies and are predisposed to several cancers, particularly acute myeloid leukemia. Defects in the DNA repair protein Fanconi Anemia D2 (FANCD2) also play an important role in the development of a variety of cancers (e.g., bladder cancer) in people without this genetic disease. This communication shows that cells deficient in FANCD2 are hypersensitive to the cytotoxicity (clonogenic assay) and DNA damage (γ-H2AX and 53BP1 focus assay) induced by caffeic acid and by a commercial lyophilized coffee extract. These data suggest that people with Fanconi Anemia, or healthy people who develop sporadic mutations in FANCD2, may be hypersensitive to the carcinogenic activity of coffee. View Full-Text
Keywords: coffee; caffeic acid; cancer; DNA damage; carcinogenesis; FANCD2; Fanconi anemia coffee; caffeic acid; cancer; DNA damage; carcinogenesis; FANCD2; Fanconi anemia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Burgos-Morón, E.; Calderón-Montaño, J.M.; Orta, M.L.; Guillén-Mancina, E.; Mateos, S.; López-Lázaro, M. Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid. Toxins 2016, 8, 211.

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