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Toxins 2016, 8(6), 182; doi:10.3390/toxins8060182

Relationship between vacA Types and Development of Gastroduodenal Diseases

1
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan
2
Department of Molecular Biology, 108 Hospital, Hanoi, Vietnam
3
Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam
4
Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Timothy L. Cover
Received: 15 March 2016 / Revised: 29 May 2016 / Accepted: 31 May 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Vacuolating Toxin)
View Full-Text   |   Download PDF [556 KB, uploaded 9 June 2016]   |  

Abstract

The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease. View Full-Text
Keywords: VacA genotypes; vacuolation; prolonged Helicobacter pylori infection; H. pylori-mediated diseases VacA genotypes; vacuolation; prolonged Helicobacter pylori infection; H. pylori-mediated diseases
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Thi Huyen Trang, T.; Thanh Binh, T.; Yamaoka, Y. Relationship between vacA Types and Development of Gastroduodenal Diseases. Toxins 2016, 8, 182.

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