Use of VacA as a Vaccine Antigen
AbstractOne of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine. View Full-Text
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Moyat, M.; Velin, D. Use of VacA as a Vaccine Antigen. Toxins 2016, 8, 181.
Moyat M, Velin D. Use of VacA as a Vaccine Antigen. Toxins. 2016; 8(6):181.Chicago/Turabian Style
Moyat, Mati; Velin, Dominique. 2016. "Use of VacA as a Vaccine Antigen." Toxins 8, no. 6: 181.
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