Use of VacA as a Vaccine Antigen
AbstractOne of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Moyat, M.; Velin, D. Use of VacA as a Vaccine Antigen. Toxins 2016, 8, 181.
Moyat M, Velin D. Use of VacA as a Vaccine Antigen. Toxins. 2016; 8(6):181.Chicago/Turabian Style
Moyat, Mati; Velin, Dominique. 2016. "Use of VacA as a Vaccine Antigen." Toxins 8, no. 6: 181.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.