Next Article in Journal / Special Issue
Relationship between vacA Types and Development of Gastroduodenal Diseases
Previous Article in Journal
Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA2 Dichotomy across Micrurus Venoms
Previous Article in Special Issue
An Overview of Helicobacter pylori VacA Toxin Biology
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessFeature PaperReview
Toxins 2016, 8(6), 181; doi:10.3390/toxins8060181

Use of VacA as a Vaccine Antigen

Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, CLE D203, CHUV, 155 Chemin des Boveresses, CH-1066 Epalinges, Switzerland
Present address: Swiss Federal Institute of Technology, Lausanne, Station 19, CH-1015 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Timothy L. Cover
Received: 22 March 2016 / Revised: 31 May 2016 / Accepted: 2 June 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Vacuolating Toxin)
View Full-Text   |   Download PDF [226 KB, uploaded 8 June 2016]

Abstract

One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine. View Full-Text
Keywords: VacA; vaccine; H. pylori VacA; vaccine; H. pylori
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Moyat, M.; Velin, D. Use of VacA as a Vaccine Antigen. Toxins 2016, 8, 181.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top