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Toxins 2016, 8(5), 151; doi:10.3390/toxins8050151

Ellagitannins in Cancer Chemoprevention and Therapy

1
Institute of Food Science & Nutrition, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Bosan Road, Multan 60800, Punjab, Pakistan
2
Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via I Maggetti 26, 61029 Urbino (PU), Italy
3
Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini (RN), Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Jia-You Fang
Received: 31 March 2016 / Revised: 28 April 2016 / Accepted: 9 May 2016 / Published: 13 May 2016
(This article belongs to the Special Issue Dietary and Non-Dietary Phytochemicals and Cancer)
View Full-Text   |   Download PDF [1232 KB, uploaded 13 May 2016]   |  

Abstract

It is universally accepted that diets rich in fruit and vegetables lead to reduction in the risk of common forms of cancer and are useful in cancer prevention. Indeed edible vegetables and fruits contain a wide variety of phytochemicals with proven antioxidant, anti-carcinogenic, and chemopreventive activity; moreover, some of these phytochemicals also display direct antiproliferative activity towards tumor cells, with the additional advantage of high tolerability and low toxicity. The most important dietary phytochemicals are isothiocyanates, ellagitannins (ET), polyphenols, indoles, flavonoids, retinoids, tocopherols. Among this very wide panel of compounds, ET represent an important class of phytochemicals which are being increasingly investigated for their chemopreventive and anticancer activities. This article reviews the chemistry, the dietary sources, the pharmacokinetics, the evidence on chemopreventive efficacy and the anticancer activity of ET with regard to the most sensitive tumors, as well as the mechanisms underlying their clinically-valuable properties. View Full-Text
Keywords: ellagitannins; phytochemicals; cancer; chemoprevention; cancer therapy; safety ellagitannins; phytochemicals; cancer; chemoprevention; cancer therapy; safety
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ismail, T.; Calcabrini, C.; Diaz, A.R.; Fimognari, C.; Turrini, E.; Catanzaro, E.; Akhtar, S.; Sestili, P. Ellagitannins in Cancer Chemoprevention and Therapy. Toxins 2016, 8, 151.

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