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Toxins 2016, 8(12), 355; doi:10.3390/toxins8120355

Fast Screening of Antibacterial Compounds from Fusaria

1
Department of Chemistry and Bioscience, Aalborg University, Frederik Bajers Vej 7H, DK-9220 Aalborg Ø, Denmark
2
Department of Animal Science, Faculty of Science and Technology, Aarhus University, Blichers Allé 20, DK-8830 Tjele, Denmark
3
Department of Chemistry and Bioscience, Aalborg University, Niels Bohrs Vej 8, 6700 Esbjerg, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Sven Dänicke
Received: 4 November 2016 / Revised: 23 November 2016 / Accepted: 25 November 2016 / Published: 29 November 2016
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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Abstract

Bio-guided screening is an important method to identify bioactive compounds from fungi. In this study we applied a fast digital time-lapse microscopic method for assessment of the antibacterial properties of secondary metabolites from the fungal genus Fusarium. Here antibacterial effects could be detected for antibiotic Y, aurofusarin, beauvericin, enniatins and fusaric acid after six hours of cultivation. The system was then used in a bio-guided screen of extracts from 14 different Fusarium species, which had been fractionated by HPLC. In this screen, fractions containing the red pigments aurofusarin and bikaverin showed effects against strains of Lactobacillus and Bifidobacterium. The IC50 for aurofusarin against Lactobacillus acidophilus was 8 µM, and against Bifidobacterium breve it was 64 µM. Aurofusarin only showed an effect on probiotic bacteria, leading to the speculation that only health-promoting bacteria with a positive effect in the gut system are affected. View Full-Text
Keywords: Fusarium; mycotoxins; secondary metabolites; bioactivity; polyketides; pigments; antibiotics; bio-guided assays; antibacterial; aurofusarin Fusarium; mycotoxins; secondary metabolites; bioactivity; polyketides; pigments; antibiotics; bio-guided assays; antibacterial; aurofusarin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sondergaard, T.E.; Fredborg, M.; Oppenhagen Christensen, A.-M.; Damsgaard, S.K.; Kramer, N.F.; Giese, H.; Sørensen, J.L. Fast Screening of Antibacterial Compounds from Fusaria. Toxins 2016, 8, 355.

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