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Toxins 2015, 7(8), 2918-2958; doi:10.3390/toxins7082918

Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?

1
Department of Microbiology, Institut de Recherche Biomédicale des Armées (IRBA), BP 73, Bretigny-sur-orge cedex F-91223, France
2
Laboratoire Pathogénie des Toxi-infections Bactériennes, Institut Pasteur, 28 rue du Docteur Roux, Paris cedex 15 F-75725, France 
Academic Editor: Holger Barth
Received: 1 April 2015 / Revised: 27 July 2015 / Accepted: 28 July 2015 / Published: 4 August 2015
(This article belongs to the Section Bacterial Toxins)
View Full-Text   |   Download PDF [979 KB, uploaded 4 August 2015]   |  

Abstract

Autophagy is a physiological process involved in defense mechanisms for clearing intracellular bacteria. The autophagic pathway is finely regulated and bacterial toxins interact with this process in a complex manner. Bacterial toxins also interact significantly with many biochemical processes. Evaluations of the effects of bacterial toxins, such as endotoxins, pore-forming toxins and adenylate cyclases, on autophagy could support the development of new strategies for counteracting bacterial pathogenicity. Treatment strategies could focus on drugs that enhance autophagic processes to improve the clearance of intracellular bacteria. However, further in vivo studies are required to decipher the upregulation of autophagy and potential side effects limiting such approaches. The capacity of autophagy activation strategies to improve the outcome of antibiotic treatment should be investigated in the future. View Full-Text
Keywords: bacterial toxins; autophagy; cyclic AMP; therapeutic targets bacterial toxins; autophagy; cyclic AMP; therapeutic targets
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mathieu, J. Interactions between Autophagy and Bacterial Toxins: Targets for Therapy? Toxins 2015, 7, 2918-2958.

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