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Toxins 2015, 7(12), 5194-5211; doi:10.3390/toxins7124877

Computational Studies of Venom Peptides Targeting Potassium Channels

Research School of Biology, Australian National University, Acton ACT 2601, Australia
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Author to whom correspondence should be addressed.
Academic Editor: Jean-Marc Sabatier
Received: 15 October 2015 / Revised: 13 November 2015 / Accepted: 20 November 2015 / Published: 1 December 2015
(This article belongs to the Special Issue Animal Toxins and Biological Ion Channels)
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Abstract

Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone. View Full-Text
Keywords: potassium channels; peptide toxins; molecular modeling; molecular dynamics potassium channels; peptide toxins; molecular modeling; molecular dynamics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, R.; Chung, S.-H. Computational Studies of Venom Peptides Targeting Potassium Channels. Toxins 2015, 7, 5194-5211.

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