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Toxins 2015, 7(12), 5167-5181; doi:10.3390/toxins7124873

Risk Assessment of Deoxynivalenol by Revisiting Its Bioavailability in Pig and Rat Models to Establish Which Is More Suitable

1
ANSES, Fougères Laboratory, Antibiotics, Biocides, Residues and Resistance Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France
2
ANSES, Fougères Laboratory, Scientific Support Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France
3
ANSES, Fougères Laboratory, Analysis of Residues and Contaminants Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Maresca
Received: 16 August 2015 / Revised: 26 October 2015 / Accepted: 18 November 2015 / Published: 1 December 2015
(This article belongs to the Section Mycotoxins)
View Full-Text   |   Download PDF [1037 KB, uploaded 1 December 2015]   |  

Abstract

Due to its toxic properties, high stability, and prevalence, the presence of deoxynivalenol (DON) in the food chain is a major threat to food safety and therefore a health risk for both humans and animals. In this study, experiments were carried out with sows and female rats to examine the kinetics of DON after intravenous and oral administration at 100 µg/kg of body weight. After intravenous administration of DON in pigs, a two-compartment model with rapid initial distribution (0.030 ± 0.019 h) followed by a slower terminal elimination phase (1.53 ± 0.54 h) was fitted to the concentration profile of DON in pig plasma. In rats, a short elimination half-life (0.46 h) and a clearance of 2.59 L/h/kg were estimated by sparse sampling non-compartmental analysis. Following oral exposure, DON was rapidly absorbed and reached maximal plasma concentrations (Cmax) of 42.07 ± 8.48 and 10.44 ± 5.87 µg/L plasma after (tmax) 1.44 ± 0.52 and 0.17 h in pigs and rats, respectively. The mean bioavailability of DON was 70.5% ± 25.6% for pigs and 47.3% for rats. In the framework of DON risk assessment, these two animal models could be useful in an exposure scenario in two different ways because of their different bioavailability. View Full-Text
Keywords: deoxynivalenol; bioavailability; toxicokinetic; risk assessment deoxynivalenol; bioavailability; toxicokinetic; risk assessment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Saint-Cyr, M.J.; Perrin-Guyomard, A.; Manceau, J.; Houée, P.; Delmas, J.-M.; Rolland, J.-G.; Laurentie, M. Risk Assessment of Deoxynivalenol by Revisiting Its Bioavailability in Pig and Rat Models to Establish Which Is More Suitable. Toxins 2015, 7, 5167-5181.

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