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Toxins 2015, 7(11), 4832-4851; doi:10.3390/toxins7114832

Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications

1,2
,
1,2
and
1,3,*
1
Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of sciences, Kunming 650223, Yunnan, China
2
University of Chinese Academy of Sciences, Beijing100009, China
3
Joint Laboratory of Natural Peptide, University of Science and Technology of China and Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
*
Author to whom correspondence should be addressed.
Academic Editor: Glenn F. King
Received: 14 October 2015 / Revised: 10 November 2015 / Accepted: 11 November 2015 / Published: 17 November 2015
(This article belongs to the Special Issue Arthropod Venoms)
View Full-Text   |   Download PDF [505 KB, uploaded 17 November 2015]   |  

Abstract

Venomous animals have evolved with sophisticated bio-chemical strategies to arrest prey and defend themselves from natural predators. In recent years, peptide toxins from venomous animals have drawn considerable attention from researchers due to their surprising chemical, biochemical, and pharmacological diversity. Similar to other venomous animals, centipedes are one of the crucial venomous arthropods that have been used in traditional medicine for hundreds of years in China. Despite signifying pharmacological importance, very little is known about the active components of centipede venoms. More than 500 peptide sequences have been reported in centipede venomous glands by transcriptome analysis, but only a small number of peptide toxins from centipede has been functionally described. Like other venomous animals such as snakes, scorpions, and spiders, the venom of centipedes could be an excellent source of peptides for developing drugs for treatments as well as bio-insecticides for agrochemical applications. Although centipede venoms are yet to be adequately studied, the venom of centipedes as well as their components described to date, should be compiled to help further research. Therefore, based on previous reports, this review focusses on findings and possible therapeutic applications of centipede venoms as well as their components. View Full-Text
Keywords: centipedes; venom; peptides; toxins; pharmacology; therapeutics centipedes; venom; peptides; toxins; pharmacology; therapeutics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hakim, M.A.; Yang, S.; Lai, R. Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications. Toxins 2015, 7, 4832-4851.

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