Acupoint Injection of Onabotulinumtoxin A for Migraines
AbstractOnabotulinumtoxin A (BoNTA) has been reported to be effective in the therapy for migraines. Acupuncture has been used worldwide for the treatment of migraine attacks. Injection of a small amount of drug at acupuncture points is an innovation as compared to traditional acupuncture. The purpose of this study was to evaluate and compare the effectiveness of fixed (muscle)-site and acupoint-site injections of BoNTA for migraine therapy in a randomized, double-blinded, placebo-controlled clinical trial extending over four months. Subjects with both episodic and chronic migraines respectively received a placebo (n = 19) or BoNTA (2.5 U each site, 25 U per subject) injection at fixed-sites (n = 41) including occipitofrontalis, corrugator supercilii, temporalis and trapeziue, or at acupoint-sites (n = 42) including Yintang (EX-HN3), Taiyang (EX-HN5), Baihui (GV20), Shuaigu (GB8), Fengchi (GB20) and Tianzhu (BL10). The variations between baseline and BoNTA post-injection for four months were calculated monthly as outcome measures. BoNTA injections at fixed-sites and acupoint-sites significantly reduced the migraine attack frequency, intensity, duration and associated symptoms for four months compared with placebo (p < 0.01). The efficacy of BoNTA for migraines in the acupoint-site group (93% improvement) was more significant than that in the fixed-site group (85% improvement) (p < 0.01). BoNTA administration for migraines is effective, and at acupoint-sites shows more efficacy than at fixed-sites. Further blinded studies are necessary to establish the efficacy of a low dose toxin (25 U) introduced with this methodology in chronic and episodic migraines. View Full-Text
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Hou, M.; Xie, J.-F.; Kong, X.-P.; Zhang, Y.; Shao, Y.-F.; Wang, C.; Ren, W.-T.; Cui, G.-F.; Xin, L.; Hou, Y.-P. Acupoint Injection of Onabotulinumtoxin A for Migraines. Toxins 2015, 7, 4442-4454.
Hou M, Xie J-F, Kong X-P, Zhang Y, Shao Y-F, Wang C, Ren W-T, Cui G-F, Xin L, Hou Y-P. Acupoint Injection of Onabotulinumtoxin A for Migraines. Toxins. 2015; 7(11):4442-4454.Chicago/Turabian Style
Hou, Min; Xie, Jun-Fan; Kong, Xiang-Pan; Zhang, Yi; Shao, Yu-Feng; Wang, Can; Ren, Wen-Ting; Cui, Guang-Fu; Xin, Le; Hou, Yi-Ping. 2015. "Acupoint Injection of Onabotulinumtoxin A for Migraines." Toxins 7, no. 11: 4442-4454.