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Toxins 2015, 7(11), 4404-4420; doi:10.3390/toxins7114404

Nodularia spumigena Peptides—Accumulation and Effect on Aquatic Invertebrates

Department of Marine Biotechnology, Institute of Oceanography, University of Gdańsk, Al. Marszałka Piłsudskiego 46, 81-378 Gdynia, Poland
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Academic Editors: Vítor Vasconcelos and Pedro Leão
Received: 8 October 2015 / Revised: 21 October 2015 / Accepted: 23 October 2015 / Published: 30 October 2015
(This article belongs to the Special Issue Bioactivity and Toxicity in Marine Cyanobacteria)
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Abstract

Thus far, the negative effects of Nodularia spumigena blooms on aquatic organisms have been mainly attributed to the production of the hepatotoxic nodularin (NOD). In the current work, the accumulation of other N. spumigena metabolites in blue mussels and crustaceans, and their effect on Thamnocephalus platyurus and Artemia franciscana, were examined. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses provided evidence that both blue mussels collected after a cyanobacterial bloom in the Baltic Sea and the crustaceans exposed under laboratory conditions to N. spumigena extract accumulated the cyclic anabaenopeptins (APs). In the crustaceans, the linear peptides, spumigins (SPUs) and aeruginosins (AERs), were additionally detected. Exposure of T. platyurus and A. franciscana to N. spumigena extract confirmed the negative effect of nodularin on the organisms. However, high numbers of dead crustaceans were also recorded in the nodularin-free fraction, which contained protease inhibitors classified to spumigins and aeruginosins. These findings indicate that cyanobacterial toxicity to aquatic organisms is a complex phenomenon and the induced effects can be attributed to diverse metabolites, not only to the known hepatotoxins. View Full-Text
Keywords: bioaccumulation; blue mussels; Baltic cyanobacteria; cyanopeptides; crustaceans; Nodularia spumigena bioaccumulation; blue mussels; Baltic cyanobacteria; cyanopeptides; crustaceans; Nodularia spumigena
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mazur-Marzec, H.; Sutryk, K.; Hebel, A.; Hohlfeld, N.; Pietrasik, A.; Błaszczyk, A. Nodularia spumigena Peptides—Accumulation and Effect on Aquatic Invertebrates. Toxins 2015, 7, 4404-4420.

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