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Toxins 2015, 7(10), 4199-4215; doi:10.3390/toxins7104199

High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses

1
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA
2
Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
3
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Maresca
Received: 17 July 2015 / Revised: 28 September 2015 / Accepted: 9 October 2015 / Published: 19 October 2015
(This article belongs to the Special Issue Mycotoxins and Human Diseases 2015)
View Full-Text   |   Download PDF [575 KB, uploaded 19 October 2015]   |  

Abstract

Deoxynivalenol (DON), a trichothecene mycotoxin that commonly contaminates cereal grains, is a public health concern because of its adverse effects on the gastrointestinal and immune systems. The objective of this study was to compare effects of DON on anorectic responses in aged (22 mos) and adult (3 mos) mice. Aged mice showed increased feed refusal with both acute i.p. (1 mg/kg and 5 mg/kg) and dietary (1, 2.5, 10 ppm) DON exposure in comparison to adult mice. In addition to greater suppression of food intake from dietary DON exposure, aged mice also exhibited greater but transient body weight suppression. When aged mice were acutely exposed to 1 mg/kg bw DON i.p., aged mice displayed elevated DON and DON3GlcA tissue levels and delayed clearance in comparison with adult mice. Acute DON exposure also elicited higher proinflammatory cytokine and satiety hormone responses in the plasma of the aged group compared with the adult group. Increased susceptibility to DON-induced anorexia in aged mice relative to adult mice suggests that advanced life stage could be a critical component in accurate human risk assessments for DON and other trichothecenes. View Full-Text
Keywords: mycotoxin; anorexia; aging; weight loss; PYY; CCK; IL-6; IL-1β; mouse mycotoxin; anorexia; aging; weight loss; PYY; CCK; IL-6; IL-1β; mouse
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Clark, E.S.; Flannery, B.M.; Gardner, E.M.; Pestka, J.J. High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses. Toxins 2015, 7, 4199-4215.

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