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Toxins 2015, 7(10), 4175-4198; doi:10.3390/toxins7104175

Bioactive Mimetics of Conotoxins and other Venom Peptides

1
CSIRO Manufacturing, Bag 10, Clayton South, VIC 3169, Australia
2
School of Chemical and Physical Sciences, Flinders University, Adelaide, SA 5042, Australia
3
School of Chemistry, Monash University, Clayton, VIC 3800, Australia
*
Authors to whom correspondence should be addressed.
Academic Editors: Macdonald Christie and Luis M. Botana
Received: 2 September 2015 / Accepted: 8 October 2015 / Published: 16 October 2015
(This article belongs to the Special Issue Conotoxins: Novel Pharmacologies for Nervous System Disorders)
View Full-Text   |   Download PDF [1299 KB, uploaded 16 October 2015]   |  

Abstract

Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include a description of how some of the initially designed mimics have been modified to improve their drug-like properties. View Full-Text
Keywords: venom peptides; toxins; conotoxins; peptidomimetics; N-type calcium channel; Cav2.2 venom peptides; toxins; conotoxins; peptidomimetics; N-type calcium channel; Cav2.2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Duggan, P.J.; Tuck, K.L. Bioactive Mimetics of Conotoxins and other Venom Peptides. Toxins 2015, 7, 4175-4198.

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