EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia
AbstractIt is crucial to define risk factors that contribute to host invasion by Staphylococcus aureus. Here, we demonstrate that the chromosomally encoded EDIN-B isoform from S. aureus contributes to the onset of bacteremia during the course of pneumonia. Deletion of edinB in a European lineage community-acquired methicillin resistant S. aureus (CA-MRSA) strain (ST80-MRSA-IV) dramatically decreased the frequency and magnitude of bacteremia in mice suffering from pneumonia. This deletion had no effect on the bacterial burden in both blood circulation and lung tissues. Re-expression of wild-type EDIN-B, unlike the catalytically inactive mutant EDIN-R185E, restored the invasive characteristics of ST80-MRSA-IV. View Full-Text
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Courjon, J.; Munro, P.; Benito, Y.; Visvikis, O.; Bouchiat, C.; Boyer, L.; Doye, A.; Lepidi, H.; Ghigo, E.; Lavigne, J.-P.; Vandenesch, F.; Lemichez, E. EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia. Toxins 2015, 7, 4131-4142.
Courjon J, Munro P, Benito Y, Visvikis O, Bouchiat C, Boyer L, Doye A, Lepidi H, Ghigo E, Lavigne J-P, Vandenesch F, Lemichez E. EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia. Toxins. 2015; 7(10):4131-4142.Chicago/Turabian Style
Courjon, Johan; Munro, Patrick; Benito, Yvonne; Visvikis, Orane; Bouchiat, Coralie; Boyer, Laurent; Doye, Anne; Lepidi, Hubert; Ghigo, Eric; Lavigne, Jean-Philippe; Vandenesch, François; Lemichez, Emmanuel. 2015. "EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia." Toxins 7, no. 10: 4131-4142.