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Toxins 2014, 6(8), 2229-2238; doi:10.3390/toxins6082229
Review

Thuringiensin: A Thermostable Secondary Metabolite from Bacillus thuringiensis with Insecticidal Activity against a Wide Range of Insects

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Received: 14 April 2014 / Revised: 16 July 2014 / Accepted: 18 July 2014 / Published: 25 July 2014
(This article belongs to the Special Issue Bacillus thuringiensis Toxins)
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Abstract

Thuringiensin (Thu), also known as β-exotoxin, is a thermostable secondary metabolite secreted by Bacillus thuringiensis. It has insecticidal activity against a wide range of insects, including species belonging to the orders Diptera, Coleoptera, Lepidoptera, Hymenoptera, Orthoptera, and Isoptera, and several nematode species. The chemical formula of Thu is C22H32O19N5P, and it is composed of adenosine, glucose, phosphoric acid, and gluconic diacid. In contrast to the more frequently studied insecticidal crystal protein, Thu is not a protein but a small molecule oligosaccharide. In this review, a detailed and updated description of the characteristics, structure, insecticidal mechanism, separation and purification technology, and genetic determinants of Thu is provided.
Keywords: thuringiensin; Bacillus thuringiensis; insecticidal mechanism; genetic determinants thuringiensin; Bacillus thuringiensis; insecticidal mechanism; genetic determinants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liu, X.; Ruan, L.; Peng, D.; Li, L.; Sun, M.; Yu, Z. Thuringiensin: A Thermostable Secondary Metabolite from Bacillus thuringiensis with Insecticidal Activity against a Wide Range of Insects. Toxins 2014, 6, 2229-2238.

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