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Structure, Function, and Biology of the Enterococcus faecalis Cytolysin
AbstractEnterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug resistant, hospital-acquired pathogen. Highly virulent strains of E. faecalis express a pore-forming exotoxin, called cytolysin, which lyses both bacterial and eukaryotic cells in response to quorum signals. Originally described in the 1930s, the cytolysin is a member of a large class of lanthionine-containing bacteriocins produced by Gram-positive bacteria. While the cytolysin shares some core features with other lantibiotics, it possesses unique characteristics as well. The current understanding of cytolysin biosynthesis, structure/function relationships, and contribution to the biology of E. faecalis are reviewed, and opportunities for using emerging technologies to advance this understanding are discussed.
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Van Tyne, D.; Martin, M.J.; Gilmore, M.S. Structure, Function, and Biology of the Enterococcus faecalis Cytolysin. Toxins 2013, 5, 895-911.View more citation formats
Van Tyne D, Martin MJ, Gilmore MS. Structure, Function, and Biology of the Enterococcus faecalis Cytolysin. Toxins. 2013; 5(5):895-911.Chicago/Turabian Style
Van Tyne, Daria; Martin, Melissa J.; Gilmore, Michael S. 2013. "Structure, Function, and Biology of the Enterococcus faecalis Cytolysin." Toxins 5, no. 5: 895-911.