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Toxins 2013, 5(12), 2353-2365; doi:10.3390/toxins5122353
Article

An Extract of Rhodobacter sphaeroides Reduces Cisplatin-Induced Nephrotoxicity in Mice

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1 Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung 402, Taiwan 2 Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan 3 Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan 4 Asia-Pacific Biotech Developing, Inc. Kaohsiung 806, Taiwan 5 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 6 Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan 7 Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 6 September 2013 / Revised: 18 November 2013 / Accepted: 25 November 2013 / Published: 29 November 2013
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Abstract

Cisplatin is used as a treatment for various types of solid tumors. Renal injury severely limits the use of cisplatin. Renal cell apoptosis, oxidative stress, and inflammation contribute to cisplatin-induced nephrotoxicity. Previously, we found that an extract of Rhodobacter sphaeroides (Lycogen™) inhibited proinflammatory cytokines and the production of nitric oxide in activated macrophages in a dextran sodium sulfate (DSS)-induced colitis model. Here, we evaluated the effect of Lycogen™, a potent anti-inflammatory agent, in mice with cisplatin-induced renal injury. We found that attenuated renal injury correlated with decreased apoptosis due to a reduction in caspase-3 expression in renal cells. Oral administration of Lycogen™ significantly reduced the expression of tumor necrosis factor-α and interleukin-1β in mice with renal injury. Lycogen™ reduces renal dysfunction in mice with cisplatin-induced renal injury. The protective effects of the treatment included blockage of the cisplatin-induced elevation in serum urea nitrogen and creatinine. Meanwhile, Lycogen™ attenuated body weight loss and significantly prolonged the survival of mice with renal injury. We propose that Lycogen™ exerts anti-inflammatory activities that represent a promising strategy for the treatment of cisplatin-induced renal injury.
Keywords: Rhodobacter sphaeroides; Lycogen™; cisplatin; nephrotoxicity Rhodobacter sphaeroides; Lycogen™; cisplatin; nephrotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chang, W.-W.; Liu, J.-J.; Liu, C.-F.; Liu, W.-S.; Lim, Y.-P.; Cheng, Y.-J.; Lee, C.-H. An Extract of Rhodobacter sphaeroides Reduces Cisplatin-Induced Nephrotoxicity in Mice. Toxins 2013, 5, 2353-2365.

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