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Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli
Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, Québec, Canada
Received: 17 September 2013; in revised form: 25 October 2013 / Accepted: 30 October 2013 / Published: 7 November 2013
Abstract: Enterotoxigenic Escherichia coli (ETEC) produces two types of enterotoxins: heat-labile (LT) and heat-stable (STa and STb). These molecules are involved in the induction of secretory diarrhea in animals including humans. This condition is currently treated using a fluid replacement therapy and antibiotics. This treatment is often not available to people in developing countries, and several die from the condition provoke by ETEC. Over the years, plants and plant extracts have been use as traditional medicine to treat various gastrointestinal ailments including diarrhea. Many of these plant products have been claimed to be active against diarrhea, however few have been extensively studied. The main objective of this review was to gather the scattered information on the antidiarrheal activities reported for various plant products on ETEC. This includes two major effects: (1) The inhibitory effect on bacterial growth or viability and (2) The interference with ETEC enterotoxins activity upon the intestinal epithelium. We will focus on plant products and extracts for which we have major indications of their biological activity against ETEC and their enterotoxins. Because Vibrio cholerae toxin (CT) is structurally, antigenically and mechanistically related to LT, it will also be discussed in this review.
Keywords: enterotoxigenic Escherichia coli; plant product; enterotoxin; antibacterial; diarrhea; treatment; traditional medicine; toxin inhibition; secretion; extracts
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MDPI and ACS Style
Dubreuil, J.D. Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli. Toxins 2013, 5, 2009-2041.
Dubreuil JD. Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli. Toxins. 2013; 5(11):2009-2041.
Dubreuil, J. D. 2013. "Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli." Toxins 5, no. 11: 2009-2041.