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Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
Department of Molecular and Cellular Biology, Institute of Biology, Federal Fluminense University, Niteroi 24020-141, RJ, Brazil
Department of Marine Biology, Institute of Biology, Federal Fluminense University, Niteroi 24020-141, RJ, Brazil
Ezequiel Dias Foundation, Belo Horizonte 30510-010, MG, Brazil
Department of Invertebrates, Federal University of Rio de Janeiro, National Museum 20940-040, RJ, Brazil
* Author to whom correspondence should be addressed.
Received: 2 August 2013; in revised form: 8 October 2013 / Accepted: 11 October 2013 / Published: 17 October 2013
Abstract: Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties.
Keywords: Brazilian sponges; Bothrops jararaca; Lachesis muta; snake venom; neutralization
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Faioli, C.N.; Domingos, T.F.S.; de Oliveira, E.C.; Sanchez, E.F.; Ribeiro, S.; Muricy, G.; Fuly, A.L. Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom. Toxins 2013, 5, 1799-1813.
Faioli CN, Domingos TFS, de Oliveira EC, Sanchez EF, Ribeiro S, Muricy G, Fuly AL. Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom. Toxins. 2013; 5(10):1799-1813.
Faioli, Camila N.; Domingos, Thaisa F.S.; de Oliveira, Eduardo C.; Sanchez, Eládio F.; Ribeiro, Suzi; Muricy, Guilherme; Fuly, Andre L. 2013. "Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom." Toxins 5, no. 10: 1799-1813.