Toxins 2012, 4(12), 1427-1439; doi:10.3390/toxins4121427
Article

Interleukin-17 (IL-17) Expression Is Reduced during Acute Myocardial Infarction: Role on Chemokine Receptor Expression in Monocytes and Their in Vitro Chemotaxis towards Chemokines

Maria Troitskaya 1,2 email, Anton Baysa 1,2 email, Jarle Vaage 3 email, Kristin L. Sand 1 email, Azzam A. Maghazachi 1,* email and Guro Valen 1,2,* email
1 Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo N-0317, Norway 2 Center for Heart Failure Research, University of Oslo, Oslo N-0317, Norway 3 Department of Emergency and Intensive Care at the Institute of Clinical Medicine, Oslo University Hospital, Oslo N-0424, Norway
* Authors to whom correspondence should be addressed.
Received: 15 November 2012; in revised form: 27 November 2012 / Accepted: 28 November 2012 / Published: 30 November 2012
(This article belongs to the Special Issue Toxicity and Therapeutic Interventions in the Immune System)
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Abstract: The roles of immune cells and their soluble products during myocardial infarction (MI) are not completely understood. Here, we observed that the percentages of IL-17, but not IL-22, producing cells are reduced in mice splenocytes after developing MI. To correlate this finding with the functional activity of IL-17, we sought to determine its effect on monocytes. In particular, we presumed that this cytokine might affect the chemotaxis of monocytes important for cardiac inflammation and remodeling. We observed that IL-17 tends to reduce the expression of two major chemokine receptors involved in monocyte chemotaxis, namely CCR2 and CXCR4. Further analysis showed that monocytes pretreated with IL-17 have reduced in vitro chemotaxis towards the ligand for CCR2, i.e., MCP-1/CCL2, and the ligand for CXCR4, i.e., SDF-1α/CXCL12. Our results support the possibility that IL-17 may be beneficial in MI, and this could be due to its ability to inhibit the migration of monocytes.
Keywords: myocardial infarction; IL-17; monocytes; chemokines; chemokine receptors

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MDPI and ACS Style

Troitskaya, M.; Baysa, A.; Vaage, J.; Sand, K.L.; Maghazachi, A.A.; Valen, G. Interleukin-17 (IL-17) Expression Is Reduced during Acute Myocardial Infarction: Role on Chemokine Receptor Expression in Monocytes and Their in Vitro Chemotaxis towards Chemokines. Toxins 2012, 4, 1427-1439.

AMA Style

Troitskaya M, Baysa A, Vaage J, Sand KL, Maghazachi AA, Valen G. Interleukin-17 (IL-17) Expression Is Reduced during Acute Myocardial Infarction: Role on Chemokine Receptor Expression in Monocytes and Their in Vitro Chemotaxis towards Chemokines. Toxins. 2012; 4(12):1427-1439.

Chicago/Turabian Style

Troitskaya, Maria; Baysa, Anton; Vaage, Jarle; Sand, Kristin L.; Maghazachi, Azzam A.; Valen, Guro. 2012. "Interleukin-17 (IL-17) Expression Is Reduced during Acute Myocardial Infarction: Role on Chemokine Receptor Expression in Monocytes and Their in Vitro Chemotaxis towards Chemokines." Toxins 4, no. 12: 1427-1439.

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