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Toxins 2011, 3(9), 1089-1110; doi:10.3390/toxins3091089
Review

Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars

1,* , 2
, 2
 and 2
Received: 11 August 2011; in revised form: 17 August 2011 / Accepted: 17 August 2011 / Published: 31 August 2011
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Abstract: Pseudomonas syringae is a phytopathogenic bacterium present in a wide variety of host plants where it causes diseases with economic impact. The symptoms produced by Pseudomonas syringae include chlorosis and necrosis of plant tissues, which are caused, in part, by antimetabolite toxins. This category of toxins, which includes tabtoxin, phaseolotoxin and mangotoxin, is produced by different pathovars of Pseudomonas syringae. These toxins are small peptidic molecules that target enzymes of amino acids’ biosynthetic pathways, inhibiting their activity and interfering in the general nitrogen metabolism. A general overview of the toxins’ chemistry, biosynthesis, activity, virulence and potential applications will be reviewed in this work.
Keywords: tabtoxin; phaseolotoxin; mangotoxin; virulence; arginine; ornithine; glutamine tabtoxin; phaseolotoxin; mangotoxin; virulence; arginine; ornithine; glutamine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Arrebola, E.; Cazorla, F.M.; Perez-García, A.; Vicente, A. Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars. Toxins 2011, 3, 1089-1110.

AMA Style

Arrebola E, Cazorla FM, Perez-García A, Vicente A. Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars. Toxins. 2011; 3(9):1089-1110.

Chicago/Turabian Style

Arrebola, Eva; Cazorla, Francisco M.; Perez-García, Alejandro; Vicente, Antonio de. 2011. "Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars." Toxins 3, no. 9: 1089-1110.



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