Toxins 2011, 3(9), 1089-1110; doi:10.3390/toxins3091089
Review

Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars

1,* email, 2email, 2email and 2email
Received: 11 August 2011; in revised form: 17 August 2011 / Accepted: 17 August 2011 / Published: 31 August 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pseudomonas syringae is a phytopathogenic bacterium present in a wide variety of host plants where it causes diseases with economic impact. The symptoms produced by Pseudomonas syringae include chlorosis and necrosis of plant tissues, which are caused, in part, by antimetabolite toxins. This category of toxins, which includes tabtoxin, phaseolotoxin and mangotoxin, is produced by different pathovars of Pseudomonas syringae. These toxins are small peptidic molecules that target enzymes of amino acids’ biosynthetic pathways, inhibiting their activity and interfering in the general nitrogen metabolism. A general overview of the toxins’ chemistry, biosynthesis, activity, virulence and potential applications will be reviewed in this work.
Keywords: tabtoxin; phaseolotoxin; mangotoxin; virulence; arginine; ornithine; glutamine
PDF Full-text Download PDF Full-Text [726 KB, Updated Version, uploaded 5 September 2011 12:35 CEST]
The original version is still available [4132 KB, uploaded 31 August 2011 14:44 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Arrebola, E.; Cazorla, F.M.; Perez-García, A.; Vicente, A. Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars. Toxins 2011, 3, 1089-1110.

AMA Style

Arrebola E, Cazorla FM, Perez-García A, Vicente A. Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars. Toxins. 2011; 3(9):1089-1110.

Chicago/Turabian Style

Arrebola, Eva; Cazorla, Francisco M.; Perez-García, Alejandro; Vicente, Antonio de. 2011. "Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars." Toxins 3, no. 9: 1089-1110.

Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert