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Toxins 2011, 3(3), 260-293; doi:10.3390/toxins3030260

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

1
Department of Biology, Faculty of Sciences, Arak University, Iran
2
Laboratory of Chemical Biology, Institut de Science et d'Ingénierie Supramoléculaires; ISIS/Université de Strasbourg, CNRS-UMR 7006, 8, allée Gaspard Monge, BP 70028, F-67083, Strasbourg Cedex, France
3
Laboratoire de Biophysicochimie des Récepteurs Canaux, UMR 7199 “Conception et Application de Molécules Bioactives” CNRS-Université de Strasbourg, 74 Route du Rhin-BP 60024, 67401 Illkirch Cedex, France
*
Author to whom correspondence should be addressed.
Received: 8 November 2010 / Revised: 1 February 2011 / Accepted: 16 March 2011 / Published: 21 March 2011
(This article belongs to the Special Issue Toxins as Therapeutics)
View Full-Text   |   Download PDF [1431 KB, 24 March 2011; original version 21 March 2011]   |  

Abstract

Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
Keywords: nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nasiripourdori, A.; Taly, V.; Grutter, T.; Taly, A. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins 2011, 3, 260-293.

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