Next Article in Journal
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process
Next Article in Special Issue
In Vitro Antiplasmodial Activity of Phospholipases A2 and a Phospholipase Homologue Isolated from the Venom of the Snake Bothrops asper
Previous Article in Journal
Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response
Previous Article in Special Issue
The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells
Toxins 2011, 3(3), 260-293; doi:10.3390/toxins3030260

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

1 Department of Biology, Faculty of Sciences, Arak University, Iran 2 Laboratory of Chemical Biology, Institut de Science et d'Ingénierie Supramoléculaires; ISIS/Université de Strasbourg, CNRS-UMR 7006, 8, allée Gaspard Monge, BP 70028, F-67083, Strasbourg Cedex, France 3 Laboratoire de Biophysicochimie des Récepteurs Canaux, UMR 7199 “Conception et Application de Molécules Bioactives” CNRS-Université de Strasbourg, 74 Route du Rhin-BP 60024, 67401 Illkirch Cedex, France
* Author to whom correspondence should be addressed.
Received: 8 November 2010 / Revised: 1 February 2011 / Accepted: 16 March 2011 / Published: 21 March 2011
(This article belongs to the Special Issue Toxins as Therapeutics)
View Full-Text   |   Download PDF [1431 KB, 24 March 2011; original version 21 March 2011]   |   Browse Figures


Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
Keywords: nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Nasiripourdori, A.; Taly, V.; Grutter, T.; Taly, A. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins 2011, 3, 260-293.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert