Toxins 2011, 3(3), 260-293; doi:10.3390/toxins3030260
Review

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

1email, 2email, 3email and 3,* email
Received: 8 November 2010; in revised form: 1 February 2011 / Accepted: 16 March 2011 / Published: 21 March 2011
(This article belongs to the Special Issue Toxins as Therapeutics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
Keywords: nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate
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MDPI and ACS Style

Nasiripourdori, A.; Taly, V.; Grutter, T.; Taly, A. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins 2011, 3, 260-293.

AMA Style

Nasiripourdori A, Taly V, Grutter T, Taly A. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins. 2011; 3(3):260-293.

Chicago/Turabian Style

Nasiripourdori, Adak; Taly, Valérie; Grutter, Thomas; Taly, Antoine. 2011. "From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules." Toxins 3, no. 3: 260-293.

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