Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Toxins 2011, 3(3), 260-293; doi:10.3390/toxins3030260
Review

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

1
, 2
, 3
 and 3,*
Received: 8 November 2010; in revised form: 1 February 2011 / Accepted: 16 March 2011 / Published: 21 March 2011
(This article belongs to the Special Issue Toxins as Therapeutics)
View Full-Text   |   Download PDF [1431 KB, updated 24 March 2011; original version uploaded 21 March 2011]
Abstract: Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
Keywords: nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Nasiripourdori, A.; Taly, V.; Grutter, T.; Taly, A. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins 2011, 3, 260-293.

AMA Style

Nasiripourdori A, Taly V, Grutter T, Taly A. From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins. 2011; 3(3):260-293.

Chicago/Turabian Style

Nasiripourdori, Adak; Taly, Valérie; Grutter, Thomas; Taly, Antoine. 2011. "From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules." Toxins 3, no. 3: 260-293.



Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert