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Toxins 2010, 2(9), 2213-2229; doi:10.3390/toxins2092213

Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C

Lehrstuhl für Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
Author to whom correspondence should be addressed.
Received: 15 July 2010 / Revised: 12 August 2010 / Accepted: 24 August 2010 / Published: 26 August 2010
(This article belongs to the Special Issue Enterotoxins)
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Enterotoxigenic Escherichia coli (ETEC) associated diarrhea is responsible for roughly half a million deaths per year, the majority taking place in developing countries. The main agent responsible for these diseases is the bacterial heat-stable enterotoxin STa. STa is secreted by ETEC and after secretion binds to the intestinal receptor guanylyl cyclase C (GC-C), thus triggering a signaling cascade that eventually leads to the release of electrolytes and water in the intestine. Additionally, GC-C is a specific marker for colorectal carcinoma and STa is suggested to have an inhibitory effect on intestinal carcinogenesis. To understand the conformational events involved in ligand binding to GC-C and to devise therapeutic strategies to treat both diarrheal diseases and colorectal cancer, it is paramount to obtain structural information on the receptor ligand system. Here we summarize the currently available structural data and report on physiological consequences of STa binding to GC-C in intestinal epithelia and colorectal carcinoma cells. View Full-Text
Keywords: heat-stable enterotoxin; guanylyl cyclase C; secretory diarrhea; colorectal cancer heat-stable enterotoxin; guanylyl cyclase C; secretory diarrhea; colorectal cancer

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Weiglmeier, P.R.; Rösch, P.; Berkner, H. Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C. Toxins 2010, 2, 2213-2229.

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