Toxins 2010, 2(6), 1554-1567; doi:10.3390/toxins2061554
Review

Procoagulant Adaptation of a Blood Coagulation Prothrombinase-like Enzyme Complex in Australian Elapid Venom

1email and 1,2,* email
Received: 30 March 2010; in revised form: 4 June 2010 / Accepted: 17 June 2010 / Published: 18 June 2010
(This article belongs to the Special Issue Protein Toxins as Proteases)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The macromolecular enzyme complex prothrombinase serves an indispensable role in blood coagulation as it catalyzes the conversion of prothrombin to thrombin, a key regulatory enzyme in the formation of a blood clot. Interestingly, a virtually identical enzyme complex is found in the venom of some Australian elapid snakes, which is composed of a cofactor factor Va-component and a serine protease factor Xa-like subunit. This review will provide an overview of the identification and characterization of the venom prothrombinase complex and will discuss the rationale for its powerful procoagulant nature responsible for the potent hemostatic toxicity of the elapid venom.
Keywords: snake venom; blood coagulation; prothrombinase complex; factor X; factor V; prothrombin activation; serine protease; hemostatic toxin
PDF Full-text Download PDF Full-Text [756 KB, uploaded 18 June 2010 15:36 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Bos, M.H.; Camire, R.M. Procoagulant Adaptation of a Blood Coagulation Prothrombinase-like Enzyme Complex in Australian Elapid Venom. Toxins 2010, 2, 1554-1567.

AMA Style

Bos MH, Camire RM. Procoagulant Adaptation of a Blood Coagulation Prothrombinase-like Enzyme Complex in Australian Elapid Venom. Toxins. 2010; 2(6):1554-1567.

Chicago/Turabian Style

Bos, Mettine H.A.; Camire, Rodney M. 2010. "Procoagulant Adaptation of a Blood Coagulation Prothrombinase-like Enzyme Complex in Australian Elapid Venom." Toxins 2, no. 6: 1554-1567.

Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert