Next Article in Journal
The Impact of Sex and 25(OH)D Deficiency on Metabolic Function in Mice
Next Article in Special Issue
Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice
Previous Article in Journal
Western Dietary Pattern Is Associated with Irritable Bowel Syndrome in the French NutriNet Cohort
Previous Article in Special Issue
Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Nutrients 2017, 9(9), 987; doi:10.3390/nu9090987

Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota

1
Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Department of Metabolism and Diabetes, Videnska 1958/9, 14021 Prague 4, Czech Republic
2
Centre of Diabetology, Institute for Clinical and Experimental Medicine, Department of Metabolism and Diabetes, Videnska 1958/9, 14021 Prague 4, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 20 June 2017 / Revised: 28 August 2017 / Accepted: 30 August 2017 / Published: 7 September 2017
(This article belongs to the Special Issue Nutrition and Liver Disease)
View Full-Text   |   Download PDF [419 KB, uploaded 12 September 2017]   |  

Abstract

Parenteral nutrition (PN) provides life-saving nutritional support in situations where caloric supply via the enteral route cannot cover the necessary needs of the organism. However, it does have serious adverse effects, including parenteral nutrition-associated liver disease (PNALD). The development of liver injury associated with PN is multifactorial, including non-specific intestine inflammation, compromised intestinal permeability, and barrier function associated with increased bacterial translocation, primary and secondary cholangitis, cholelithiasis, short bowel syndrome, disturbance of hepatobiliary circulation, lack of enteral nutrition, shortage of some nutrients (proteins, essential fatty acids, choline, glycine, taurine, carnitine, etc.), and toxicity of components within the nutrition mixture itself (glucose, phytosterols, manganese, aluminium, etc.). Recently, an increasing number of studies have provided evidence that some of these factors are directly or indirectly associated with microbial dysbiosis in the intestine. In this review, we focus on PN-induced changes in the taxonomic and functional composition of the microbiome. We also discuss immune cell and microbial crosstalk during parenteral nutrition, and the implications for the onset and progression of PNALD. Finally, we provide an overview of recent advances in the therapeutic utilisation of pro- and prebiotics for the mitigation of PN-associated liver complications. View Full-Text
Keywords: Parenteral nutrition; microbiota; PNALD; intestinal permeability; gut-associated immune system; bile acids; FXR signalling; pre/probiotics Parenteral nutrition; microbiota; PNALD; intestinal permeability; gut-associated immune system; bile acids; FXR signalling; pre/probiotics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cahova, M.; Bratova, M.; Wohl, P. Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota. Nutrients 2017, 9, 987.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top