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Nutrients 2017, 9(9), 956; doi:10.3390/nu9090956

Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses

Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421, Japan
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Received: 11 July 2017 / Revised: 21 August 2017 / Accepted: 25 August 2017 / Published: 30 August 2017
(This article belongs to the Special Issue Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health)
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Abstract

The clinical significance of polyunsaturated fatty acids (PUFAs) in acute decompensated heart failure (ADHF) in various nutritional statuses remains unclear. For this study, we enrolled 267 patients with ADHF admitted to the cardiac intensive care unit at Juntendo University hospital between April 2012 and March 2014. The association between long-term mortality, the geriatric nutritional risk index (GNRI), and levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) was investigated. The median age was 73 (64–82) years, and mortality was 29% (62 patients). The event-free survival rates for all-cause death were higher in patients with high PUFA levels or GNRI than in those with low PUFA levels or GNRI (p < 0.05 for all). In particular, high DGLA in the low-GNRI group and high DHA or AA in the high-GNRI group were associated with high event-free survival (p < 0.05 for all). After accounting for confounding variables, DHA, DGLA, and AA, but not EPA, were associated with long-term mortality (p < 0.01 for all). This study concludes that in patients with ADHF, decreased levels of DHA, DGLA, and AA are independently associated with long-term mortality in the various nutritional statuses. View Full-Text
Keywords: polyunsaturated fatty acids (PUFAs); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); dihomo-gamma-linolenic acid (DGLA); arachidonic acid (AA); geriatric nutritional risk index (GNRI); acute decompensated heart failure (ADHF); nutritional status polyunsaturated fatty acids (PUFAs); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); dihomo-gamma-linolenic acid (DGLA); arachidonic acid (AA); geriatric nutritional risk index (GNRI); acute decompensated heart failure (ADHF); nutritional status
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MDPI and ACS Style

Ouchi, S.; Miyazaki, T.; Shimada, K.; Sugita, Y.; Shimizu, M.; Murata, A.; Kato, T.; Aikawa, T.; Suda, S.; Shiozawa, T.; Hiki, M.; Takahashi, S.; Iwata, H.; Kasai, T.; Miyauchi, K.; Daida, H. Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses. Nutrients 2017, 9, 956.

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