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Nutrients 2017, 9(9), 955; doi:10.3390/nu9090955

Dietary Fish and Long-Chain n-3 Polyunsaturated Fatty Acids Intake and Risk of Atrial Fibrillation: A Meta-Analysis

1,†
,
2,3,†
,
4 and 1,*
1
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510000, Guangdong, China
2
Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou 215000, Jiangsu, China
3
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 546080, Singapore
4
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, Hunan , China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 July 2017 / Revised: 16 August 2017 / Accepted: 25 August 2017 / Published: 29 August 2017
(This article belongs to the Special Issue Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health)
View Full-Text   |   Download PDF [1515 KB, uploaded 31 August 2017]   |  

Abstract

Findings on the association between long-term intake of fish or long-chain n-3 polyunsaturated fatty acids (PUFAs) and risk of atrial fibrillation (AF) are inconsistent in observational studies. We conducted a meta-analysis of prospective studies to separately examine the associations between fish consumption and dietary intake of n-3 PUFAs with the risk of AF. A systematic search was conducted in PubMed and Embase to identify relevant studies. Risk estimates were combined using a random-effect model. Seven prospective cohort studies covering 206,811 participants and 12,913 AF cases were eligible. The summary relative risk of AF for the highest vs. lowest category of fish consumption and dietary intake of n-3 PUFAs was 1.01(95% confidence interval: 0.94–1.09) and 1.03 (95% confidence interval: 0.97–1.09), respectively. These null associations persisted in subgroup and dose-response analyses. There was little evidence of publication bias. This meta-analysis suggests that neither long-term intake of fish, nor of n-3 PUFAs were significantly associated with lower risk of AF. View Full-Text
Keywords: fish; n-3 polyunsaturated fatty acids; atrial fibrillation; meta-analysis fish; n-3 polyunsaturated fatty acids; atrial fibrillation; meta-analysis
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MDPI and ACS Style

Li, F.-R.; Chen, G.-C.; Qin, J.; Wu, X. Dietary Fish and Long-Chain n-3 Polyunsaturated Fatty Acids Intake and Risk of Atrial Fibrillation: A Meta-Analysis. Nutrients 2017, 9, 955.

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