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Nutrients 2017, 9(9), 1017; doi:10.3390/nu9091017

A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders

1
Neuromuscular Reference Centre, Ghent University Hospital, 9000 Ghent, Belgium
2
Department of Pediatrics-Division of Pediatric Neurology and Metabolism, Ghent University Hospital, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Received: 8 August 2017 / Revised: 1 September 2017 / Accepted: 11 September 2017 / Published: 14 September 2017
(This article belongs to the Special Issue Effects of Resveratrol Supplementation on Human Health and Disease)
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Abstract

In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential innovative strategies aim to ameliorate mitochondrial function by increasing the total mitochondrial load of tissues and/or to scavenge the excess of reactive oxygen species generated by OXPHOS malfunctioning. In this respect, resveratrol, a compound that conveniently combines mitogenetic with antioxidant activities and, as a bonus, possesses anti-apoptotic properties, has come forward as a promising nutraceutical. We review the scientific evidence gathered so far through experiments in both in vitro and in vivo systems, evaluating the therapeutic effect that resveratrol is expected to generate in mitochondrial patients. The obtained results are encouraging, but clearly show that achieving normalization of OXPHOS function with this strategy alone could prove to be an unattainable goal. View Full-Text
Keywords: mitochondrial biogenesis; mitochondrial disorders; oxidative phosphorylation; resveratrol mitochondrial biogenesis; mitochondrial disorders; oxidative phosphorylation; resveratrol
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De Paepe, B.; Van Coster, R. A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders. Nutrients 2017, 9, 1017.

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