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Nutrients 2017, 9(8), 909; doi:10.3390/nu9080909

Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern

1
Fundación IIS-Fundación Jiménez Díaz, 28040 Madrid, UAM, Spain
2
Allergy Department, Hospital Central de Asturias, 33011 Oviedo, Spain
3
Unidad Alergia, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain
4
Facultad de Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain
5
Departamento de Biotecnología, ETS Ingenieros Agrónomos, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 2 June 2017 / Revised: 11 August 2017 / Accepted: 17 August 2017 / Published: 21 August 2017
(This article belongs to the Special Issue Nutrition and Allergic Diseases)
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Abstract

Introduction: Different clinical and molecular patterns of food allergy have been reported in different areas of the world. The aim of the study is to evaluate differences in allergen patterns among nut-allergic patients in two different areas of Spain. Material and methods: A total of 77 patients with nut allergy from two different regions of Spain (Madrid and Asturias) were evaluated. Results: Hazelnut, peanut, and walnut were the three most frequent nuts eliciting allergy in both regions, but in a different order. Patients from Madrid experienced systemic reactions more often than patients from Asturias (73.5% Madrid vs. 50.0%, p < 0.05). The percentage of sensitizations to LTP (Lipid Transfer Protein) was higher than Bet v 1 (p < 0.05) in the Madrid area. The percentage of sensitizations in Asturias area was similar to LTP than Bet v 1 (Pru p 3 46.4%, Bet v 1 42.9%, ns). Bet v 1 was the predominant allergen involved among hazelnut-allergic patients (56.2%), while LTP was more common in peanut-allergic patients (61.5%). Conclusion: Walnut, hazelnut, and peanut were the most frequent nuts eliciting allergy in Spain. Despite this, important differences in molecular pattern were appreciated not only between both regions, but also among nut-allergic patients in Asturias. The different molecular pattern was linked to the frequency of systemic symptoms. View Full-Text
Keywords: nut allergy; peanut; walnut; hazelnut; Bet v 1; LTP; Pru p 3; Phl p 12 nut allergy; peanut; walnut; hazelnut; Bet v 1; LTP; Pru p 3; Phl p 12
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Haroun-Díaz, E.; Azofra, J.; González-Mancebo, E.; de las Heras, M.; Pastor-Vargas, C.; Esteban, V.; Villalba, M.; Díaz-Perales, A.; Cuesta-Herranz, J. Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. Nutrients 2017, 9, 909.

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