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Nutrients 2017, 9(8), 867; doi:10.3390/nu9080867

The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial

1
Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD 4226, Australia
2
Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
3
National Institute of Integrative Medicine, Melbourne, VIC 3122, Australia
4
School of Allied Health, La Trobe University, Melbourne, VIC 3086, Australia
5
Division of Cancer Services, Princess Alexandra Hospital, and Institute of Health and Biomedical Innovation, Brisbane, QLD 4102, Australia
6
School of Nursing, University of Auckland, Auckland 1010, New Zealand
7
School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia
8
Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia
9
Medlab Clinical Ltd., Alexandria, Sydney, NSW 2015, Australia
*
Author to whom correspondence should be addressed.
Received: 30 June 2017 / Revised: 7 August 2017 / Accepted: 8 August 2017 / Published: 12 August 2017
View Full-Text   |   Download PDF [485 KB, uploaded 12 August 2017]   |  

Abstract

Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic factors. Over three consecutive chemotherapy cycles, nausea was more prevalent than vomiting (47% vs. 12%). In chemotherapy Cycle 1, intervention participants reported significantly better QoL related to CIN (p = 0.029), chemotherapy-induced nausea and vomiting (CINV)-related QoL (p = 0.043), global QoL (p = 0.015) and less fatigue (p = 0.006) than placebo participants. There were no significant results in Cycle 2. In Cycle 3, global QoL (p = 0.040) and fatigue (p = 0.013) were significantly better in the intervention group compared to placebo. This trial suggests adjuvant ginger supplementation is associated with better chemotherapy-induced nausea-related quality of life and less cancer-related fatigue, with no difference in adverse effects compared to placebo. View Full-Text
Keywords: ginger; nausea; CINV; dietary supplements; cancer; emesis ginger; nausea; CINV; dietary supplements; cancer; emesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Marx, W.; McCarthy, A.L.; Ried, K.; McKavanagh, D.; Vitetta, L.; Sali, A.; Lohning, A.; Isenring, E. The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial. Nutrients 2017, 9, 867.

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