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Nutrients 2017, 9(8), 861; doi:10.3390/nu9080861

The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans—A Randomized Placebo-Controlled Study

1
Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
2
St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Level 5 deLacy Building, St Vincent’s Hospital, Victoria St., Darlinghurst, NSW 2010, Australia
3
School of Medical Sciences, Faculty of Medicine, University of New South Wales, 18 High St., Kensington, Sydney, NSW 2052, Australia
4
Department of Endocrinology, St. Vincent’s Hospital, 390 Victoria St., Darlinghurst, NSW 2010, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 15 June 2017 / Revised: 1 August 2017 / Accepted: 9 August 2017 / Published: 11 August 2017
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Abstract

Background: High dietary acid load relates to increased risk of type 2 diabetes in epidemiological studies. We aimed to investigate whether buffering a high acid load meal with an alkalizing treatment changes glucose metabolism post meal. Methods: Non-diabetic participants (n = 32) were randomized to receive either 1680 mg NaHCO3 or placebo, followed by a high acid load meal in a double-blind placebo-controlled crossover (1–4 weeks apart) study. Thirty (20 men) participants completed the study. Venous blood pH, serum bicarbonate, blood glucose, serum insulin, C-peptide, non-esterified fatty acid (NEFA), and plasma glucagon-like peptide-1 (GLP-1) concentrations were measured at baseline (fasting) and at 15–30 min intervals for 3 h post meal. Results: The treatment was well tolerated. Venous blood pH declined in the first 15 min post meal with the placebo (p = 0.001), but not with NaHCO3 (p = 0.86) and remained decreased with the placebo for 3 h (pinteraction = 0.04). On average over the 3 h blood pH iAUC was greater with NaHCO3 compared with placebo (p = 0.02). However, postprandial glucose, insulin, C-peptide, NEFA and GLP-1 were not different between treatments (pinteraction ≥ 0.07). Conclusions: An alkalizing medication administered pre-meal has no acute effect on glycaemia and insulin response in healthy individuals. Long-term interventions in at-risk populations are necessary to investigate the effect of sustained alkalization on glucose metabolism. View Full-Text
Keywords: alkaline diet; dietary acid load; type 2 diabetes; acid-base homeostasis; sodium bicarbonate; postprandial glycaemia alkaline diet; dietary acid load; type 2 diabetes; acid-base homeostasis; sodium bicarbonate; postprandial glycaemia
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MDPI and ACS Style

Kozan, P.; Blythe, J.C.; Greenfield, J.R.; Samocha-Bonet, D. The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans—A Randomized Placebo-Controlled Study. Nutrients 2017, 9, 861.

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